Title :
Gender-Specific Effects of Health and Lifestyle Markers on Individual BrainAGE
Author :
Franke, Katrin ; Ristow, Michael ; Gaser, Christian
Author_Institution :
Struct. Brain Mapping Group, Univ. Hosp. Jena, Jena, Germany
Abstract :
This study quantifies the effects of health and lifestyle markers on individual brain aging in dementia-free elderly subjects, revealed by a relevance vector regression approach. In males, markers of metabolic syndrome as well as alcohol abuse were significantly related to increased Brain AGE scores of up to 9 years. In females, markers of healthy liver and kidney functions and an adequate supply of nutrients were significantly related to decreased Brain AGE scores.
Keywords :
age issues; brain; diseases; gender issues; kidney; liver; medical disorders; regression analysis; BrainAGE; alcohol abuse; brain aging; dementia free elderly subject; gender specific effect; healthy liver marker; kidney function; lifestyle marker; metabolic syndrome marker; nutrient supply; relevance vector regression approach; Aging; Atrophy; Brain modeling; Dementia; Magnetic resonance imaging; Physiology; Aging; Alzheimer´s disease; BrainAGE; Lifestyle; Magnetic resonance imaging; Voxel-based morphometry;
Conference_Titel :
Pattern Recognition in Neuroimaging (PRNI), 2013 International Workshop on
Conference_Location :
Philadelphia, PA
DOI :
10.1109/PRNI.2013.33
