A miniaturized lock-in amplifier design suitable for impedance measurements in cells [biological cells]

Author

Moe, Andrew E. ; Marx, Steve R. ; Bhinderwala, Iqbal ; Wilson, Denise M.

Author_Institution

Dept. of Electr. Eng., Univ. of Washington, Seattle, WA, USA

fYear

2004

fDate

24-27 Oct. 2004

Firstpage

215

Abstract

A comparison of the performance for impedance analysis of biological cells between a newly fabricated miniature lock-in amplifier and an industry standard Stanford Research SR830 lock-in amplifier is described. Experimental results compare measurement error over a range of characteristic model impedances from 1 kHz to 10 MHz. Within the functional frequency range of the SR830, the miniaturized lock-in amplifier performs with approximately 30% less precision than the SR830. At higher frequencies, that are more suitable for impedance analysis in biological cells, however, the miniaturized lock-in continues to perform with less than 10% average error while the SR830 fails to operate entirely. With consistent performance at higher frequencies, this miniaturized lock-in amplifier is a desirable instrument for use in biological impedance analysis.

Keywords

biosensors; electric impedance measurement; instrumentation amplifiers; measurement errors; 1 kHz to 10 MHz; biological cell impedance analysis; biological impedance analysis; impedance measurement; measurement error; measurement precision; miniaturized lock-in amplifier; Amplifiers; Biological cells; Biological system modeling; Cells (biology); Failure analysis; Frequency; Impedance measurement; Measurement errors; Performance analysis; Textile industry;

fLanguage

English

Publisher

ieee

Conference_Titel

Sensors, 2004. Proceedings of IEEE

Print_ISBN

0-7803-8692-2

Type

conf

DOI

10.1109/ICSENS.2004.1426139

Filename

1426139