Title :
Microfluidic bischemical analysis system
Author :
Anderson, Rolfe C. ; Bogdan, Gregory J. ; Bamiv, Zuri ; Dawes, Timothy D. ; Winkler, James ; Roy, Kajal
Author_Institution :
Affymetrix Inc., Santa Clara, CA, USA
Abstract :
We have developed a genetic-analysis system that integrates all reactions necessary to process a sample and use a microfabricated GeneChip(R) polynucleotide array. This system has performed a multistep assay for monitoring mutations in the HIV virus in 10 μL reaction volumes. The microfluidic structures and thermal control methods demonstrated in this work can be generally applied to integrate other chemical and biochemical analysis systems
Keywords :
biological techniques; chemical analysis; chemical reactions; proteins; HIV virus; biochemical analysis; genetic-analysis; hybridisation; integrated reactors; microfabricated GeneChip(R) polynucleotide array; microfluidic bischemical analysis; microfluidic structures; multistep assay; mutations; thermal control; Automatic testing; Biochemical analysis; Chemical analysis; Control systems; Costs; Genetics; Inductors; Lab-on-a-chip; Microfluidics; Monitoring;
Conference_Titel :
Solid State Sensors and Actuators, 1997. TRANSDUCERS '97 Chicago., 1997 International Conference on
Conference_Location :
Chicago, IL
Print_ISBN :
0-7803-3829-4
DOI :
10.1109/SENSOR.1997.613690
