In vitro Degradation Behavior of Photopolymerized PEG Hydrogels as Tissue Engineering Scaffold

Author

Xin, Antonio X. ; Gaydos, Celeste ; Mao, Jeremy J.

Author_Institution

Dept. of Dental Med. & Biomed. Eng., Columbia Univ., New York, NY

fYear

2006

fDate

Aug. 30 2006-Sept. 3 2006

Firstpage

2091

Lastpage

2093

Abstract

PEGDA was photopolymerized to form hydrogels under different UV light irradiation times. In order to investigate the degradation rate in vitro, the various PEGDA hydrogels were incubated in PBS solution at 37degC in shaking water bath system. The physical-chemical properties such as pH values, dimension, mass and volume change, compressive strength and Young´s modulus were measured. MALDI-MS and SEM were employed to evaluate the PBS solutions and corroded hydrogels after a designed period of time till 8 weeks. The results indicate that the PEGDA formed hydrogels can be tailored with prompted properties specifically for various cell-based tissue engineering needs

Keywords

Young´s modulus; biodegradable materials; biomedical materials; cellular biophysics; compressive strength; polymer gels; polymerisation; scanning electron microscopy; time of flight mass spectroscopy; tissue engineering; ultraviolet radiation effects; 37 C; SEM; UV light irradiation; Young´s modulus; cell-based tissue engineering; compressive strength; in vitro degradation behavior; matrix-assisted laser desorption-ionization time-of-flight mass spectrometry; pH values; photopolymerization; physical-chemical properties; poly (ethylene glycol) diacrylate hydrogel; shaking water bath system; tissue engineering scaffold; Analysis of variance; Cities and towns; Degradation; Dentistry; In vitro; Statistical analysis; Surface morphology; Testing; Tissue engineering; USA Councils;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE

Conference_Location

New York, NY

ISSN

1557-170X

Print_ISBN

1-4244-0032-5

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2006.260811

Filename

4462199