Towards non-invasive and continuous monitoring of blood glucose level based on CW photoacoustics: New concept for selective and sensitive measurements of aqueous glucose

This paper describes the concept of combining two protocols based on the continuous-wave photoacoustic technique for selective and sensitive measurement of glucose compounds. The first protocol, equivalent to an acoustic velocity measurement, provides a highly sensitive measurement of glucose as well as other parameters. The second protocol exhibits sensitivity to compounds depending on the optical wavelength used for the generation of acoustic waves. By multiplying the number of optical wavelengths used, it is then possible to obtain a system of M independent equations with N unknown parameters, including glucose concentration. Solving the system combining the results from the two protocols should then provide selective and sensitive measurement of diluted glucose non-invasively and continuously.