Title :
Surface-Modification Superparamagnetic Nanoparticles for Highly-Efficient Intracellular Hyperthermia
Author :
Wang, Xiaowen ; Kan, Sixing ; Zhao, Lingyun ; Tang, Jintian ; Chen, Benke
Author_Institution :
Key Lab. of Particle & Radiat. Imaging, Tsinghua Univ., Beijing, China
Abstract :
Functionalized superparamagnetic iron oxide nanoparticles (SPIONs) can play crucial roles for medical applications such as cancer magnetic induction hyperthermia, magnetic resonance imaging and magnetofection. Herein we report the results of modified magnetic nanoparticles coated with protamine peptides containing nuclear localization signal sequences. Functionalization of these SPIONs under alternating magnetic field radiation resulted in more cellular uptake and higher-efficient cytotoxicity in HepG2 cells. The work demonstrates that functionalized SPIONs can be used as a novel kind of highly efficient magnetic mediator for magnetic induction intracellular hyperthermia.
Keywords :
biomedical materials; biomolecular effects of radiation; cancer; cellular biophysics; cellular effects of radiation; hyperthermia; molecular biophysics; nanobiotechnology; nanoparticles; proteins; cancer magnetic induction hyperthermia; cytotoxicity; magnetic induction intracellular hyperthermia; magnetic resonance imaging; magnetofection; protamine peptides; superparamagnetic iron oxide nanoparticles; superparamagnetic nanoparticles; Biomedical equipment; Cancer; Hyperthermia; Iron; Magnetic fields; Magnetic resonance imaging; Medical services; Nanoparticles; Peptides; Sequences;
Conference_Titel :
Bioinformatics and Biomedical Engineering (iCBBE), 2010 4th International Conference on
Conference_Location :
Chengdu
Print_ISBN :
978-1-4244-4712-1
Electronic_ISBN :
2151-7614
DOI :
10.1109/ICBBE.2010.5516427
