Title :
Synthesis of Novel Ursolic Acid Derivatives
Author :
Meng, Yan-Qiu ; Xia, Yan ; Yan, Zhao-Kai ; Li, Yun-Yun ; Song, Yan-Ling
Author_Institution :
Dept. of Pharm. Eng., Shenyang Univ. of Chem. Technol., Shenyang, China
Abstract :
To investigate anti-tumor structure-activity relation- ship of derivatives of ursolic acid and obtain more effective anti-tumor compounds, 12 ursolic acid derivatives (10 novel compounds) with modified structures at the C-3 and C-28 position were synthesized. The structures of all compounds were confirmed by ESI-MS, IR and 1H-NMR spectral date.
Keywords :
nuclear magnetic resonance; pharmaceutical technology; tumours; ESI-MS; H-NMR; IR spectral date; anti-tumor structure-activity relationship; ursolic acid derivatives; ursolic acid synthesis; Chemical technology; Design engineering; Humans; Immune system; Neoplasms; Pharmaceuticals; Powders; Power engineering and energy; Protons; Silicon compounds;
Conference_Titel :
Bioinformatics and Biomedical Engineering (iCBBE), 2010 4th International Conference on
Conference_Location :
Chengdu
Print_ISBN :
978-1-4244-4712-1
Electronic_ISBN :
2151-7614
DOI :
10.1109/ICBBE.2010.5516467
