Carbon nanotube based biosensors

Author

Atashbar, Massood Z. ; Bejcek, Bruce ; Singamaneni, Srikanth ; Santucci, Sandro

Author_Institution

Electr. & Comput. Eng. Dept., Western Michigan Univ., Kalamazoo, MI, USA

fYear

2004

fDate

24-27 Oct. 2004

Firstpage

1048

Abstract

We describe a single wall carbon nanotube (SWNT) based biological sensor for the detection of biomolecules like Streptavidin and IgG. SWNTs have been employed for two types of sensing mechanisms: changes in the electrical conductance of the carbon nanotube matrix on non-covalent binding of biomolecules to the side walls of the carbon nanotubes; quantification of mass uptake of the matrix on biomolecule incubation. Both sensing mechanisms exhibit consistent and highly sensitive responses. Biomolecular immobilization on the carbon nanotube surface was monitored by atomic force microscopy.

Keywords

atomic force microscopy; biosensors; carbon nanotubes; electric admittance; macromolecules; mass; Streptavidin; atomic force microscopy; biomolecular immobilization; biomolecule detection; biomolecule incubation; carbon nanotube based biosensors; carbon nanotube matrix; electrical conductance; mass uptake; monoclonal immunoglobulin G; noncovalent binding; single wall carbon nanotube based biological sensor; Atomic force microscopy; Atomic measurements; Biosensors; Carbon nanotubes; Electrodes; Face detection; Glass; Molecular biophysics; Proteins; Substrates;

fLanguage

English

Publisher

ieee

Conference_Titel

Sensors, 2004. Proceedings of IEEE

Print_ISBN

0-7803-8692-2

Type

conf

DOI

10.1109/ICSENS.2004.1426354

Filename

1426354