DNA detection by self-assembled nano-particle and integrated photodiodes

We propose a silicon integrated circuit (IC) compatible DNA detection platform based on the interaction of self-assembled nano-metallic particles and ordinary visible light. The DNA hybridization initiates the formation of an opaque area at the surface of the support. A photodiode array fabricated underneath the supporting surface can then be used to detect the light intensity changes before and after the assembly of the nano-particle; the signal can be further amplified by silver enhancement.