Comparison of Intensity Based Similarity Measures forMatching Genomic Structures in Microscopic Images of Living Cells

Author

Bhattacharya, Sambit ; Acharya, Raj ; Pliss, Artem ; Malyavantham, Kishore S. ; Berezney, Ronald

Author_Institution

Dept. of Math. & Comput. Sci., Fayetteville State Univ., NC

fYear

2006

fDate

Aug. 30 2006-Sept. 3 2006

Firstpage

3057

Lastpage

3061

Abstract

This paper presents our comparative study of the application of intensity based similarity measures to the problem of matching genomic structures in microscopic images of living cells. As part of our ongoing research, we present here for the first time evidence from experiments and simulations that show the benefit of using an iterative matching algorithm guided by an intensity based similarity measure. Our experimental results are compared against a gold standard and suggest the measures that work best in the presence of fluorescent decay and other problems inherent to time-lapse microscopy. This makes our approach widely applicable in the study of the dynamics of living cells with time-lapse microscopic imaging

Keywords

DNA; biological techniques; cellular biophysics; iterative methods; molecular biophysics; optical microscopy; fluorescent decay; genomic structure matching; intensity based similarity measures; iterative matching algorithm; living cells; microscopic images; time-lapse microscopy; Bioinformatics; Biology; Computer science; Data mining; Genomics; Image registration; Iterative algorithms; Iterative closest point algorithm; Microscopy; Time measurement;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE

Conference_Location

New York, NY

ISSN

1557-170X

Print_ISBN

1-4244-0032-5

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2006.260165

Filename

4462442