The Mahalanobis distance as a metric in dynamic light scattering particle size analysis: model studies

Author

Dubin, Stephen ; Zietz, Stanley ; Gabriel, Karl L. ; Gabriel, David

Author_Institution

Dept. of Math., Phys. & Comput. Sci., Univ. of the Sci. in Philadelphia, Philadelphia, PA, USA

fYear

2001

fDate

2001

Firstpage

67

Lastpage

68

Abstract

Dynamic Light Scattering (DLS) has been applied to examination of several clinically and biologically important materials including the lens of the eye. The clinical potential of DLS has been demonstrated empirically both in vivo and in vitro. The data supplied by DLS investigation is inherently multivariate and its most efficient interpretation requires a multivariate approach which includes the variability among specimens as well as any correlation among the variables (e.g., across the particle size distribution). The authors discuss the Mahalanobis distance as a metric for statistical analysis of DLS data using model-generated data

Keywords

bio-optics; biomedical measurement; eye; light scattering; particle size measurement; statistical analysis; Mahalanobis distance; biologically important materials; clinical potential; correlation among variables; dynamic light scattering particle size analysis; eye lens; model studies; model-generated data; variability among specimens; Autocorrelation; Fluctuations; Histograms; Lenses; Light scattering; Mathematical model; Particle measurements; Particle scattering; Statistical analysis; Testing;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 2001. Proceedings of the IEEE 27th Annual Northeast

Conference_Location

Storrs, CT

Print_ISBN

0-7803-6717-0

Type

conf

DOI

10.1109/NEBC.2001.924723

Filename

924723