Synthesis of Water-Soluble Quaternized Chitosans and Their Antitumor Activity

Author

Dong, Fang ; Xue, Qinzhao ; Liu, Jingli ; Ren, Jianming ; Guo, Zhanyong

Author_Institution

Yantai Inst. of Coastal Zone Res. for Sustainable Dev., CAS, Yantai, China

fYear

2010

fDate

18-20 June 2010

Firstpage

1

Lastpage

3

Abstract

Water-soluble low-molecular-weight chitosan(LCTS) was prepared by hydrogen peroxide oxidation method and their quaternized derivatives(QLCTS) was also synthesized using previous methods. Their antitumor activity was studied, and the results showed that the LMW and its quaternized derivatives inhibited the growth of pancreatic carcinoma cell strain PANC-1 in vitro, and the inhibitory rate reached 59.2%.

Keywords

biochemistry; biological organs; biomedical materials; cancer; cellular biophysics; drugs; hydrogen compounds; infrared spectra; molecular biophysics; organic compounds; oxidation; polymers; tumours; H₂O₂; LCTS; LMW; QLCTS; antitumor activity; hydrogen peroxide oxidation; low-molecular-weight chitosan; pancreatic carcinoma cell strain PANC-1; water-soluble quaternized chitosan; Biological materials; Biomedical materials; Cancer; Chemical analysis; Content addressable storage; Oxidation; Pancreas; Sea measurements; Statistical analysis; Viscosity;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedical Engineering (iCBBE), 2010 4th International Conference on

Conference_Location

Chengdu

ISSN

2151-7614

Print_ISBN

978-1-4244-4712-1

Electronic_ISBN

2151-7614

Type

conf

DOI

10.1109/ICBBE.2010.5516546

Filename

5516546