Title :
Synthesis of Water-Soluble Quaternized Chitosans and Their Antitumor Activity
Author :
Dong, Fang ; Xue, Qinzhao ; Liu, Jingli ; Ren, Jianming ; Guo, Zhanyong
Author_Institution :
Yantai Inst. of Coastal Zone Res. for Sustainable Dev., CAS, Yantai, China
Abstract :
Water-soluble low-molecular-weight chitosan(LCTS) was prepared by hydrogen peroxide oxidation method and their quaternized derivatives(QLCTS) was also synthesized using previous methods. Their antitumor activity was studied, and the results showed that the LMW and its quaternized derivatives inhibited the growth of pancreatic carcinoma cell strain PANC-1 in vitro, and the inhibitory rate reached 59.2%.
Keywords :
biochemistry; biological organs; biomedical materials; cancer; cellular biophysics; drugs; hydrogen compounds; infrared spectra; molecular biophysics; organic compounds; oxidation; polymers; tumours; H2O2; LCTS; LMW; QLCTS; antitumor activity; hydrogen peroxide oxidation; low-molecular-weight chitosan; pancreatic carcinoma cell strain PANC-1; water-soluble quaternized chitosan; Biological materials; Biomedical materials; Cancer; Chemical analysis; Content addressable storage; Oxidation; Pancreas; Sea measurements; Statistical analysis; Viscosity;
Conference_Titel :
Bioinformatics and Biomedical Engineering (iCBBE), 2010 4th International Conference on
Conference_Location :
Chengdu
Print_ISBN :
978-1-4244-4712-1
Electronic_ISBN :
2151-7614
DOI :
10.1109/ICBBE.2010.5516546
