Title :
Modeling the dynamic composition of engineered tissues
Author :
Wilson, Christopher G. ; Kohles, Sean S. ; Bonassar, Lawrence J.
Author_Institution :
Dept. of Biomed. Eng., Worcester Polytech. Inst., MA, USA
Abstract :
Investigation of the mechanisms underlying scaffold degradation and neotissue synthesis is essential to predicting the mechanical and biological performance of engineered tissues. Modeling the dynamic composition of cell-polymer constructs may be useful in estimating the long-term mechanical performance of the engineered tissue. In this preliminary study, we fit mathematical models of scaffold mass loss and extracellular matrix synthesis to previously published data
Keywords :
biological tissues; biomechanics; biomedical materials; cellular biophysics; physiological models; biological performance; cell-polymer constructs; dynamic composition modeling; engineered tissues; extracellular matrix synthesis; long-term mechanical performance; mathematical models; mechanical performance; neotissue synthesis; scaffold degradation; scaffold mass loss; Biodegradable materials; Biological system modeling; Biological tissues; Biomedical engineering; Degradation; Electrochemical machining; Engineering in medicine and biology; Extracellular; Mathematical model; Polymers;
Conference_Titel :
Bioengineering Conference, 2001. Proceedings of the IEEE 27th Annual Northeast
Conference_Location :
Storrs, CT
Print_ISBN :
0-7803-6717-0
DOI :
10.1109/NEBC.2001.924731
