Investigation of Early Liver Radiation Injury Using Resovist-Enhanced MRI at 3T

Author

Jao, Jo-Chi ; Lu, Hsin-Ying ; Lu, Hsiang-Chin ; Liu, Gin-Chung ; Shih-Hsie Chen ; Lian, Shi-Long ; Yang, Sheau-Fang ; Chen, Po-Chou

Author_Institution

Dept. of Med. Imaging & Radiol. Sci., Kaohsiung Med. Univ., Kaohsiung, Taiwan

fYear

2010

fDate

18-20 June 2010

Firstpage

1

Lastpage

4

Abstract

The aim of this study was to investigate the rat liver injury caused by radiation using contrast enhanced magnetic resonance imaging (MRI) at 3T. The contrast agent used was Resovist, a kind of commercialized superparamagnetic iron oxide (SPIO). SPIO particles can be macrophaged by Kupffer cells after intravenous injection. The macrophaged SPIO particles make the MR signal decrease because of the susceptibility effect. When liver has injury caused by radiation, the macrophage function of Kupffer cells decreases. Once the Kupffer cells malfunction, the MR signal of irradiated liver decreases less than normal liver after SPIO administration. Therefore, liver radiation injury can be detected. The MR signal enhancement varies with the magnetic field strength, pulse sequences, injected SPIO doses and duration after SPIO injection. Three to four days after rat´s liver was irradiated with 30 Gy X-ray, the MR signal enhancement of rat liver at 3T after 80 μmol/kg body weight Resovist injection was investigated in this study.

Keywords

biological effects of X-rays; biomedical MRI; image enhancement; injuries; iron compounds; liver; medical image processing; superparamagnetism; FeO; Kupffer cells; MR signal enhancement; contrast enhanced magnetic resonance imaging; early liver radiation injury; macrophage; magnetic field strength; magnetic flux density 3 T; pulse sequences; radiation absorbed dose 30 Gy; resovist-enhanced MRI; superparamagnetic iron oxide; Biomedical imaging; Commercialization; Computed tomography; Hospitals; Injuries; Iron; Liver; Magnetic resonance imaging; Signal to noise ratio; X-ray imaging;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedical Engineering (iCBBE), 2010 4th International Conference on

Conference_Location

Chengdu

ISSN

2151-7614

Print_ISBN

978-1-4244-4712-1

Electronic_ISBN

2151-7614

Type

conf

DOI

10.1109/ICBBE.2010.5517191

Filename

5517191