A bio-magnetic bead separator on glass chips using semi-encapsulated spiral electromagnets

Author

Liakopoulos, Trifon M. ; Choi, Jin-Woo ; Ahn, Chong H.

Author_Institution

Dept. of Electr. & Comput. Eng., Cincinnati Univ., OH, USA

Volume

1

fYear

1997

fDate

16-19 Jun 1997

Firstpage

485

Abstract

A new planar bio-magnetic bead separator on a glass chip has been designed, fabricated and tested. The separator is composed of micromachined semi-encapsulated spiral electromagnets and fluid channels, which are separately fabricated and then bonded. The device was tested with super-paramagnetic beads of mean diameter 0.83 μm which were suspended in a buffered solution with solid concentration 10%. When a DC current of 300 mA was applied to the inductor, the bio-magnetic beads were successfully attached on the electromagnets, showing a functional capability as a magnetic bead separator. Using this separator, cells or cell fragments and magnetic beads bonded with protein or enzyme suspended in bio-buffer solutions can be successfully separated from their suspensions

Keywords

biological techniques; biomagnetism; cellular biophysics; electromagnets; magnetic separation; micromechanical devices; proteins; 0.83 mum; 300 mA; DC current; bio-buffer solutions; bio-magnetic bead separator; buffered solution; cell fragments; enzyme; fluid channels; functional capability; glass chips; micromachined semiencapsulated spiral electromagnets; protein; super-paramagnetic beads; Biomagnetics; Bonding; Electromagnets; Glass; Magnetic levitation; Magnetic separation; Particle separators; Solids; Spirals; Testing;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid State Sensors and Actuators, 1997. TRANSDUCERS '97 Chicago., 1997 International Conference on

Conference_Location

Chicago, IL

Print_ISBN

0-7803-3829-4

Type

conf

DOI

10.1109/SENSOR.1997.613692

Filename

613692