What we learn from multimodal co-registration methods for stereotactic imaging: from here to where?

CT, MRI, PET and SPECT 3D coregistered imaging is state-of-art in determination of the treatment planning in stereotactic radiotherapy. Stereotactic correlation of these images needs accurate localization. For it, a device measures the accuracy of CT, MRI, PET and SPECT based images on measured x, y coordinates of target positions in space. Various methods of multimodal image-fusion quantify the dimensionality, spatial resolution and tissue target geometry. New emerging imaging methods are very specific to gene and biomolecules and pose challenge of registration.