Chromatographic chiral separation on chiral stationary phase by HPLC: Cellulose 4-methylbenzoate beads as chiral stationary phase for chiral separation of some racemates by high performance liquid chromatography

Author

Han, Xiaoqian ; Zhang, Dabing ; Liu, Wanliang ; Cui, Hong ; An, Lili

Author_Institution

Coll. of Chem. & Biol. Eng., Lanzhou Jiaotong Univ., Lanzhou, China

fYear

2011

fDate

16-18 April 2011

Firstpage

4850

Lastpage

4853

Abstract

The spherical beads were first systhesized by cellulose 4-methylbenzoate with partial hydroxyl groups, which was then crosslinked in the beads with 4, 4´-diphenylmethane dissocyanate. The obtained crosslinked beads were packed into an HPLC column and used as chiral stationary phase (CSP) for chiral separation of some racemates by high performance liquid chromatography (HPLC) using mobile phases contained with 1-hexane and different alcohols. The influence of the concentration and structure of alcoholic modifiers on separation were investigated. Among the tested racemates, four racemates were first separated on this CSP. The loading capacity of cellulose 4-methylbenzoate beads for racemic Trögger base was investigated.

Keywords

chirality; chromatography; organic compounds; separation; swelling; 1-hexane; 4, 4´-diphenylmethane dissocyanate; HPLC column; alcoholic modifiers; cellulose 4-methylbenzoate beads; chiral stationary phase; chromatographic chiral separation; crosslinked beads; high performance liquid chromatography; loading capacity; mobile phases; partial hydroxyl groups; racemates; racemic Trogger base; spherical beads; Chemicals; Loading; Methanol; Mobile communication; Silicon compounds; Solvents; cellulose tris(4-methylbenzoate) spherical beads; chiral stationary phase; chromatographic chiral separation;

fLanguage

English

Publisher

ieee

Conference_Titel

Consumer Electronics, Communications and Networks (CECNet), 2011 International Conference on

Conference_Location

XianNing

Print_ISBN

978-1-61284-458-9

Type

conf

DOI

10.1109/CECNET.2011.5768455

Filename

5768455