Diffuse Optical Tomography maximizing localized variation in optical properties

A new regularization method is introduced to the inverse problem in diffuse optical tomography to improve the localization of the reconstructed abnormal optical properties. The regularization term is designed to minimize the regions and to maximize the peak value of the optical properties. Numerical simulations show the proposed method successfully reconstructs the localized abnormal region. The selection and the effects of the regularization parameters are discussed through some numerical simulations. The proposed method can be effective for screening of the breast cancer in the early stages.