Design of periodic control systems for circadian rhythm of mammals

Author

Kusumi, Tetsuya ; Ohmori, Hiromitsu

Author_Institution

Grad. Sch. of Sci. & Technol., Keio Univ., Yokohoma

fYear

2008

fDate

20-22 Aug. 2008

Firstpage

1400

Lastpage

1404

Abstract

Recently, developing molecular biology and system biology, the mechanism of the circadian rhythm in which the inside of the body rhythm of the living thing is ruled is being clarified at the cell level. On the other hand, it is said that various sicknesses are related in the medicine and pharmacology to the disorder of the circadian rhythm. Therefore, it is thought that to restore an altered rhythm is a goal of these therapies. In this paper, we study the 10-states circadian model of Drosophila and propose a close-loop control based on flatness-based adaptive control to achieve circadian rhythm restoration.

Keywords

adaptive control; biocontrol; circadian rhythms; closed loop systems; molecular biophysics; periodic control; body rhythm; cell level; circadian rhythm restoration; close-loop control; flatness-based adaptive control; living thing; mammal; molecular biology; periodic control system; system biology; Adaptive control; Biological control systems; Biological system modeling; Cancer; Cells (biology); Circadian rhythm; Control systems; Neoplasms; Systems biology; Temperature; Adaptive control; Circadian rhythm; Flatness-based control; Synchronization control; System biology;

fLanguage

English

Publisher

ieee

Conference_Titel

SICE Annual Conference, 2008

Conference_Location

Tokyo

Print_ISBN

978-4-907764-30-2

Electronic_ISBN

978-4-907764-29-6

Type

conf

DOI

10.1109/SICE.2008.4654877

Filename

4654877