DocumentCode :
3176179
Title :
Vulnerability in a one-dimensional transmural model of human ventricular tissue in heart failure
Author :
Kharche, S. ; Holden, A.V. ; Zhang, H.
Author_Institution :
Biol. Phys. Group, Manchester Univ.
fYear :
2005
fDate :
25-28 Sept. 2005
Firstpage :
563
Lastpage :
566
Abstract :
Heart failure (HF) induces remodeling in cellular ionic channel kinetics and calcium handling in the ventricle. In the present study, we investigated the effects of HF on rate dependent electrical activity of human ventricular myocytes by characterizing the dynamic action potential duration restitution (APDr), action potential (AP) alternans, intracellular calcium transient ([Ca2+]i) alternans, and delayed after depolarizations (DADs) AP. Conduction velocity restitution (CVr) and vulnerability window (VW) of homogeneous tissue to reentry subject to DAD was investigated. Vulnerability of transmural ventricular strand was also quantified under normal (NF) and HF conditions
Keywords :
bioelectric potentials; biological tissues; biomembrane transport; calcium; cardiovascular system; APDr; Ca2+; calcium handling; cellular ionic channel kinetics remodeling; conduction velocity restitution; dynamic action potential duration restitution; heart failure; human ventricular myocyte; intracellular calcium transient; rate dependent electrical activity; transmural human ventricular tissue model; vulnerability window; Astronomy; Calcium; Current density; Hafnium; Heart; Humans; Kinetic theory; Noise measurement; Physics; Strontium;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Computers in Cardiology, 2005
Conference_Location :
Lyon
Print_ISBN :
0-7803-9337-6
Type :
conf
DOI :
10.1109/CIC.2005.1588163
Filename :
1588163
Link To Document :
https://search.ricest.ac.ir/dl/search/defaultta.aspx?DTC=49&DC=3176179
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