• DocumentCode
    3178295
  • Title

    Physiological role of transverse-axial tubular system in cardiac ventricular myocytes: a simulation study

  • Author

    Pasek, M. ; Simurda, J. ; Orchard, C.H. ; Christe, G.

  • Author_Institution
    Inst. of Thermomech., Czech Acad. of Sci., Brno
  • fYear
    2005
  • fDate
    25-28 Sept. 2005
  • Firstpage
    993
  • Lastpage
    995
  • Abstract
    Experimental data related to the transverse-axial tubular system of guinea pig and rat ventricular myocytes were incorporated into quantitative models of their electrical activity. The results of simulations suggest that activity-dependent depletion of Ca2+ within the tubular lumen decreases the intracellular Ca2+ load and intracellular Ca2+ transients in both species. However, considerable species differences in the magnitude of the depletion, its frequency dependence and the resulting effect on cellular activity were observed
  • Keywords
    bioelectric phenomena; biomembrane transport; calcium; cardiology; muscle; Ca2+; activity-dependent depletion; cardiac ventricular myocyte; cellular activity; electrical activity; guinea pig; intracellular Ca2+; transverse-axial tubular system; tubular lumen; Biomembranes; Cardiology; Frequency dependence; Microscopy; Mouth; Physiology; Principal component analysis; Solid modeling; Steady-state; Thermomechanical processes;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Computers in Cardiology, 2005
  • Conference_Location
    Lyon
  • Print_ISBN
    0-7803-9337-6
  • Type

    conf

  • DOI
    10.1109/CIC.2005.1588276
  • Filename
    1588276
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=3178295