Title :
Physiological role of transverse-axial tubular system in cardiac ventricular myocytes: a simulation study
Author :
Pasek, M. ; Simurda, J. ; Orchard, C.H. ; Christe, G.
Author_Institution :
Inst. of Thermomech., Czech Acad. of Sci., Brno
Abstract :
Experimental data related to the transverse-axial tubular system of guinea pig and rat ventricular myocytes were incorporated into quantitative models of their electrical activity. The results of simulations suggest that activity-dependent depletion of Ca2+ within the tubular lumen decreases the intracellular Ca2+ load and intracellular Ca2+ transients in both species. However, considerable species differences in the magnitude of the depletion, its frequency dependence and the resulting effect on cellular activity were observed
Keywords :
bioelectric phenomena; biomembrane transport; calcium; cardiology; muscle; Ca2+; activity-dependent depletion; cardiac ventricular myocyte; cellular activity; electrical activity; guinea pig; intracellular Ca2+; transverse-axial tubular system; tubular lumen; Biomembranes; Cardiology; Frequency dependence; Microscopy; Mouth; Physiology; Principal component analysis; Solid modeling; Steady-state; Thermomechanical processes;
Conference_Titel :
Computers in Cardiology, 2005
Conference_Location :
Lyon
Print_ISBN :
0-7803-9337-6
DOI :
10.1109/CIC.2005.1588276
