Title :
Combination of gene expression and genome copy number alteration has a prognostic value for breast cancer
Author :
Cava, C. ; Zoppis, I. ; Mauri, G. ; Ripamonti, M. ; Gallivanone, F. ; Salvatore, C. ; Gilardi, M.C. ; Castiglioni, I.
Author_Institution :
Inst. of Mol. Bioimaging & Physiol., Milan, Italy
Abstract :
Specific genome copy number alterations, such as deletions and amplifications are an important factor in tumor development and progression, and are also associated with changes in gene expression. By combining analyses of gene expression and genome copy number we identified genes as candidate biomarkers of BC which were validated as prognostic factors of the disease progression. These results suggest that the proposed combined approach may become a valuable method for BC prognosis.
Keywords :
cancer; genomics; tumours; breast cancer; disease progression; gene expression; genome amplifications; genome copy number alteration; genome deletions; prognostic factors; prognostic value; tumor development; tumor progression; Accuracy; Bioinformatics; Breast cancer; Gene expression; Genomics; Support vector machines;
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE
Conference_Location :
Osaka
DOI :
10.1109/EMBC.2013.6609573
