Title :
Computer-aided tissue engineering for bone regeneration
Author :
Rainer, Alberto ; Mozetic, Pamela ; Giannitelli, Sara M. ; Accoto, Dino ; De Porcellinis, Stefano ; Guglielmelli, Eugenio ; Trombetta, Marcella
Author_Institution :
Tissue Eng. Lab., Univ. Campus Bio-Medico di Roma, Rome, Italy
Abstract :
Computer-aided tissue engineering comprises a set of methodologies for the fabrication of prosthetic implants by means of rapid prototyping technologies. The paper presents a technique for the preparation of bioactive implants intended to be used in combination with mesenchymal stem cells for the regeneration of bone tissue. The methodology uses additive manufacturing of scaffolds according to a topological optimization algorithm and combines it with chemical functionalization protocols to increase material bioactivity.
Keywords :
bone; computer aided manufacturing; medical computing; optimisation; prosthetics; rapid prototyping (industrial); tissue engineering; topology; additive manufacturing; bioactive implants; bone regeneration; bone tissue; chemical functionalization protocols; computer-aided tissue engineering; material bioactivity; mesenchymal stem cells; prosthetic implants; rapid prototyping technologies; topological optimization algorithm; Bones; Computational modeling; Computer architecture; Fabrication; Materials; Stress; Tissue engineering;
Conference_Titel :
Biomedical Robotics and Biomechatronics (BioRob), 2012 4th IEEE RAS & EMBS International Conference on
Conference_Location :
Rome
Print_ISBN :
978-1-4577-1199-2
DOI :
10.1109/BioRob.2012.6290894
