The feasibility study on 3-dimensional fluorescent x-ray computed tomography using the pinhole effect for biomedical applications

Author

Sunaguchi, Naoki ; Yuasa, Takeshi ; Hyodo, Kazuyuki ; Zeniya, Tsutomu

Author_Institution

Grad. Sch. of Eng., Gunma Univ., Kiryu, Japan

fYear

2013

fDate

3-7 July 2013

Firstpage

2348

Lastpage

2351

Abstract

We propose a 3-dimensional fluorescent x-ray computed tomography (CT) pinhole collimator, aimed at providing molecular imaging with quantifiable measures and sub-millimeter spatial resolution. In this study, we demonstrate the feasibility of this concept and investigate imaging properties such as spatial resolution, contrast resolution and quantifiable measures, by imaging physical phantoms using a preliminary imaging system developed with monochromatic synchrotron x rays constructed at the BLNE-7A experimental line at KEK, Japan.

Keywords

biomedical optical imaging; collimators; computerised tomography; diagnostic radiography; fluorescence; medical image processing; phantoms; 3-dimensional fluorescent X-ray computed tomography; BL E-7A experimental line; biomedical applications; contrast resolution; imaging properties; molecular imaging; monochromatic synchrotron X rays; physical phantoms; pinhole collimator; pinhole effect; preliminary imaging system; spatial resolution; submillimeter spatial resolution; Charge coupled devices; Fluorescence; Image reconstruction; Imaging; Photonics; Spatial resolution; X-ray imaging;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE

Conference_Location

Osaka

ISSN

1557-170X

Type

conf

DOI

10.1109/EMBC.2013.6610009

Filename

6610009