Optically-induced dielectrophoretic technology for cancer cells identification and concentration

The detection and concentration of cancer cells in peripheral blood is of great importance for cancer diagnosis and prognosis. Optically-induced dielectrophoresis (ODEP) can achieve high resolution and low optical intensities, and the electrodes pattern can be dynamically changed by varied light pattern. In this paper, a special lens is used to project the entire image to the ODEP chip to achieve 2.6×2 mm² manipulating area. By changing projected light pattern, it is demonstrated to separate 10, 20, and 40μm PS (polystyrene) beads; HT-29, 20μm PS beads. The MCF-7 cells concentrated experiments are also demo at 100 μm/sec velocity.