Identification of essential proteins based on network capital assessment and invalidating protein node

The Elimination of Protein Node Method (EPNM) destroy network topology and leading to the non-connectivity of the network. In this paper, we define accessibility of protein nodes, and develop a new Network Capital Assessment and Invalidating Protein (NCAIP) algorithm which is based on the network capital assessment and invalidating protein node. NCAIP algorithm evaluates the importance of nodes and identifies essential proteins in protein-protein interaction network by analyzing the declining extent of network capital before and after that protein node was invalidated. The experimental results show that NCAIP algorithm has high accuracy on the identification of essential proteins.