DocumentCode
3199104
Title
Determination of residual organic solvents in pharmaceuticals by headspace gas chromatography
Author
Fang, Tan ; Ma Fang-lan
Author_Institution
Key Lab. of Optoelectron. Chem. Mater. & Devices of Minist. of Educ., Jianghan Univ., Wuhan, China
Volume
2
fYear
2012
fDate
3-5 Aug. 2012
Firstpage
1004
Lastpage
1006
Abstract
A determination method of residual solvents in pharmaceutical products by headspace gas chromatography has been established and optimized. Eight solvents which belong to the guideline for residual solvents regulated by the International Conference on Harmonization were studied. Under optimum conditions, various components were separated completely. This novel method was applied to the analysis of volatile residual solvents in pharmaceutical products with satisfactory results. The method is simple, accurate and reliable, which can be used to detect the residual solvents in pharmaceutical products.
Keywords
chromatography; organic compounds; pharmaceuticals; separation; eadspace gas chromatography; optimum conditions; pharmaceutical products; residual organic solvent determination; volatile residual solvents; Instruments; gas chromatography; headspace; pharmaceutical products; residual solvents;
fLanguage
English
Publisher
ieee
Conference_Titel
Information Technology in Medicine and Education (ITME), 2012 International Symposium on
Conference_Location
Hokodate, Hokkaido
Print_ISBN
978-1-4673-2109-9
Type
conf
DOI
10.1109/ITiME.2012.6291471
Filename
6291471
Link To Document