• DocumentCode
    3199819
  • Title

    Stability and bifurcation analysis of Hodgkin-Huxley model

  • Author

    Yue Zhang ; Kuanquan Wang ; Yongfeng Yuan ; Dong Sui ; Henggui Zhang

  • Author_Institution
    Biocomput. Res. Center, Harbin Inst. of Technol., Harbin, China
  • fYear
    2013
  • fDate
    18-21 Dec. 2013
  • Firstpage
    49
  • Lastpage
    54
  • Abstract
    Hodgkin-Huxley(HH) equation is a classical model in electrophysiology and has been studied by many scholars. Applying stability theory, and taking maximal sodium conductance g̅na and potassium conductance g̅k as variables, in this study we analyze the stability and bifurcations of the model. Bifurcations are found when the variables change, and bifurcation points and boundary are calculated. When g̅na is the variable, there is only one bifurcation point and there are two points when g̅k is variable. The (g̅na, g̅k) plane is partitioned into two regions and the upper bifurcation boundary is similar to a line when both g̅na and g̅k are variables. The results gotten could be a help to control relevant diseases caused by maximal conductance anomaly.
  • Keywords
    bifurcation; bioelectric phenomena; diseases; electrical conductivity; physiological models; potassium; sodium; Hodgkin-Huxley equation; Hodgkin-Huxley model; bifurcation analysis; bifurcation points; classical model; diseases; electrophysiology; maximal conductance anomaly; maximal sodium conductance; potassium conductance; stability analysis; stability theory; upper bifurcation boundary; variable change; Analytical models; Bifurcation; Eigenvalues and eigenfunctions; Mathematical model; Stability analysis; Thermal stability; HH; bifurcation; conductance; stability;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Bioinformatics and Biomedicine (BIBM), 2013 IEEE International Conference on
  • Conference_Location
    Shanghai
  • Type

    conf

  • DOI
    10.1109/BIBM.2013.6732717
  • Filename
    6732717