DocumentCode
3199819
Title
Stability and bifurcation analysis of Hodgkin-Huxley model
Author
Yue Zhang ; Kuanquan Wang ; Yongfeng Yuan ; Dong Sui ; Henggui Zhang
Author_Institution
Biocomput. Res. Center, Harbin Inst. of Technol., Harbin, China
fYear
2013
fDate
18-21 Dec. 2013
Firstpage
49
Lastpage
54
Abstract
Hodgkin-Huxley(HH) equation is a classical model in electrophysiology and has been studied by many scholars. Applying stability theory, and taking maximal sodium conductance g̅na and potassium conductance g̅k as variables, in this study we analyze the stability and bifurcations of the model. Bifurcations are found when the variables change, and bifurcation points and boundary are calculated. When g̅na is the variable, there is only one bifurcation point and there are two points when g̅k is variable. The (g̅na, g̅k) plane is partitioned into two regions and the upper bifurcation boundary is similar to a line when both g̅na and g̅k are variables. The results gotten could be a help to control relevant diseases caused by maximal conductance anomaly.
Keywords
bifurcation; bioelectric phenomena; diseases; electrical conductivity; physiological models; potassium; sodium; Hodgkin-Huxley equation; Hodgkin-Huxley model; bifurcation analysis; bifurcation points; classical model; diseases; electrophysiology; maximal conductance anomaly; maximal sodium conductance; potassium conductance; stability analysis; stability theory; upper bifurcation boundary; variable change; Analytical models; Bifurcation; Eigenvalues and eigenfunctions; Mathematical model; Stability analysis; Thermal stability; HH; bifurcation; conductance; stability;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioinformatics and Biomedicine (BIBM), 2013 IEEE International Conference on
Conference_Location
Shanghai
Type
conf
DOI
10.1109/BIBM.2013.6732717
Filename
6732717
Link To Document