Title :
Algorithmic complexity of motifs clusters superfamilies of networks
Author :
Zenil, Hector ; Kiani, Narsis A. ; Tegner, Jesper
Author_Institution :
Unit of Comput. Med., Karolinska Institutet, Stockholm, Sweden
Abstract :
Representing biological systems as networks has proved to be very powerful. For example, local graph analysis of substructures such as subgraph over representation (or motifs) has elucidated different sub-types of networks. Here we report that using numerical approximations of Kolmogorov complexity, by means of algorithmic probability, clusters different classes of networks. For this, we numerically estimate the algorithmic probability of the sub-matrices from the adjacency matrix of the original network (hence including motifs). We conclude that algorithmic information theory is a powerful tool supplementing other network analysis techniques.
Keywords :
bioinformatics; biological techniques; information theory; network analysis; numerical analysis; probability; Kolmogorov complexity; algorithmic complexity; algorithmic information theory; algorithmic probability; biological systems; motif cluster superfamilies; network analysis techniques; numerical approximation; subtype local graph analysis; Algorithm design and analysis; Approximation algorithms; Approximation methods; Biological information theory; Complexity theory; Proteins; Kolmogorov complexity; algorithmic probability; complex networks; information content; information theory; network motifs; network typology;
Conference_Titel :
Bioinformatics and Biomedicine (BIBM), 2013 IEEE International Conference on
Conference_Location :
Shanghai
DOI :
10.1109/BIBM.2013.6732768