Title :
Sensitivity of biological tissues and cellurar cultures to repetitive submicrosecond microwave pulses
Author :
Rostov, V.V. ; Bolshakov, M.A. ; Buldakov, M.A. ; Knyazeva, I.R. ; Kutenkov, O.P. ; Litvyakov, N.V. ; Zharkova, L.P. ; Cherdyntseva, N.V.
Author_Institution :
Siberian Div., Russian Acad. of Sci., Tomsk, Russia
fDate :
June 28 2009-July 2 2009
Abstract :
The effect of repetitive pulsed microwaves (10 GHz, 100-300 ns pulse duration, 4-25 s-1 pulse repetition rate, 0.7-17.4 kW/cm2 peak power density) on mastocytoma P815 and Ehrlich carcinoma was investigated. Short-time irradiation of these tumors at 0.9-1.5 kW/cm2 inhibited proliferation of tumor cells, induced oxidative modification of macromolecules, and changed the impedance characteristics of a mitochondrial suspension of mouse hepatocytes, stimulating the wound healing. The effects showed a dependence on pulse repetition rate and irradiation intensity.
Keywords :
bioelectric phenomena; biological effects of microwaves; biomolecular effects of radiation; cellular biophysics; tumours; wounds; Ehrlich carcinoma; biological tissues; cellular cultures; frequency 10 GHz; impedance characteristics; macromolecule oxidative modification; mastocytoma P815; mouse hepatocyte mitochondrial suspension; repetitive pulsed microwave effects; repetitive submicrosecond microwave pulses; short time irradiation; time 100 ns to 300 ns; tumor cell proliferation inhibition; wound healing; Biological tissues; Cancer; DNA; Electrical resistance measurement; Impedance; Liver; Mice; Skin; Testing; Wounds;
Conference_Titel :
Pulsed Power Conference, 2009. PPC '09. IEEE
Conference_Location :
Washington, DC
Print_ISBN :
978-1-4244-4064-1
Electronic_ISBN :
978-1-4244-4065-8
DOI :
10.1109/PPC.2009.5386107
