Title :
Beat to beat variability of embryonic chick heart cells under septic conditions: Application and evaluation of entropy as well as fractal measures
Author :
Ahammer, Helmut ; Scherubel, Susanne ; Arnold, Rinaldo ; Zorn-Pauly, Klaus ; Pelzmann, Brigitte
Author_Institution :
Inst. of Biophys., Med. Univ. of Graz, Graz, Austria
Abstract :
Extracardiac factors of heart rate variability have commonly been investigated using linear and nonlinear methods for a long time. Recently, intracardiac mechanisms on an electrophysiological basis have been found to be also important. This work is focused on the evaluation of complex measures of temporal signals gained with microelectrode measurements of embryonic chick heart aggregates. Septic conditions were mimicked in vitro by lipopolysaccharide (LPS) administration in order to investigate the influence on beat to beat variability. Surrogate data analysis revealed high statistical significances for normalized complexity measures.
Keywords :
Gaussian noise; biochemistry; bioelectric potentials; biomimetics; cardiology; cellular biophysics; data analysis; entropy; fractals; microelectrodes; molecular biophysics; statistical analysis; beat-beat variability; electrophysiological basis; embryonic chick heart cell; entropy application; entropy evaluation; extracardiac factor; fractal measure; heart rate variability; intracardiac mechanism; lipopolysaccharide administration; microelectrode measurement; nonlinear method; normalized complexity measure; septic condition; surrogate data analysis; temporal signal evaluation; Complexity theory; DH-HEMTs; Entropy; Fractals; Heart rate variability; Pacemakers;
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE
Conference_Location :
Osaka
DOI :
10.1109/EMBC.2013.6610811
