Title :
Open flow microperfusion-a novel approach for a hypoglycaemia warning device
Author :
Schaupp, L. ; Ellmerer, M. ; Trajanoski, Z. ; Brunner, G.A. ; Pieber, T.R. ; Skrabal, F. ; Wach, P.
Author_Institution :
Inst. of Biomed. Eng., Graz Univ. of Technol., Austria
fDate :
31 Oct-3 Nov 1996
Abstract :
A system to monitor the subcutaneous tissue glucose concentration continuously and ex vivo with a portable device is presented. The method of open flow microperfusion was evaluated during hyperinsulinemic hypoglycaemic clamp experiments in 6 healthy volunteers. During these experiments good agreement (correlation coefficients 0.85-0.95, n=65-91) between blood glucoseand subcutaneous tissue glucose concentration could be observed. In conclusion, it could be shown that monitoring subcutaneous tissue glucose concentrations during hypoglycaemia is feasible with open flow microperfusion
Keywords :
biosensors; patient monitoring; correlation coefficient; enzyme-based biosensor; healthy volunteers; hyperinsulinemic hypoglycaemic clamp experiments; medical instrumentation; open flow microperfusion; portable device; subcutaneous tissue glucose concentration monitoring system; Amperometric sensors; Blood; Calibration; Catheters; Clamps; Conductivity; Monitoring; Sensor arrays; Sugar; Temperature sensors;
Conference_Titel :
Engineering in Medicine and Biology Society, 1996. Bridging Disciplines for Biomedicine. Proceedings of the 18th Annual International Conference of the IEEE
Conference_Location :
Amsterdam
Print_ISBN :
0-7803-3811-1
DOI :
10.1109/IEMBS.1996.656855
