A microsieve for leukocyte depletion of erythrocyte concentrates

Author

van Rijn, Cees ; Nijdam, Wietze ; Elwenspoek, Miko

Author_Institution

MESA Res. Inst., Twente Univ., Enschede, Netherlands

Volume

1

fYear

1996

fDate

31 Oct-3 Nov 1996

Firstpage

256

Abstract

A new ultra thin filtration membrane has been used for leukocyte removal from erythrocyte concentrates. This filtration membrane, an Aquamarijn Microsieve(R), has a high pore density and a narrow pore size distribution and shows good separation behaviour. The low surface roughness of the microsieve will contribute to the biocompatibility and will reduce cell rupture, in particular hemolysis, during filtration. In this paper a brief overview of the effects that occur during filtration will be given. Also the results of the experiments of leukocyte removal from erythrocyte concentrates will be discussed

Keywords

biological techniques; biomedical equipment; blood; cellular biophysics; filtration; membranes; micromachining; micromechanical devices; porosity; separation; Aquamarijn Microsieve; biocompatibility; erythrocyte concentrates; hemolysis; high pore density; leukocyte depletion; leukocyte removal; low surface roughness; micromachined sieve; microsieve; narrow pore size distribution; reduced cell rupture; separation behaviour; ultrathin filtration membrane; Biomembranes; Cells (biology); Dry etching; Filters; Filtration; Rough surfaces; Silicon; Surface roughness; Testing; White blood cells;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1996. Bridging Disciplines for Biomedicine. Proceedings of the 18th Annual International Conference of the IEEE

Conference_Location

Amsterdam

Print_ISBN

0-7803-3811-1

Type

conf

DOI

10.1109/IEMBS.1996.656941

Filename

656941