Model development for electrical stimulation of a large number of interacting axons

Author

Lin, Jim-Cheng ; Durand, Dominique M.

Author_Institution

Appl. Neural Control Lab., Case Western Reserve Univ., Cleveland, OH, USA

Volume

1

fYear

1996

fDate

31 Oct-3 Nov 1996

Firstpage

353

Abstract

A model is presented for studying point source electrical stimulation of a nerve containing a large number of axons. Axons with a given radius distribution are modeled as conducting lines distributed randomly within the nerve. The transmembrane potential can be calculated from a set of linear equations. Both the effect of the individual axon radius on the membrane potential and the contribution of the secondary current sources generated by axons to the membrane potential can be analyzed. The results show that the secondary sources generated by the fiber bundle around an individual axon can significantly affect the transmembrane voltage along its length

Keywords

bioelectric phenomena; biomembranes; cellular biophysics; neurophysiology; physiological models; electrophysiology; interacting axons interaction; linear equations set; model development; point source electrical stimulation; radius distribution; secondary current sources; transmembrane potential; transmembrane voltage; Biomedical engineering; Biomembranes; Conductivity; Electrical stimulation; Electronic mail; Engine cylinders; Equations; Immune system; Laboratories; Nerve fibers;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1996. Bridging Disciplines for Biomedicine. Proceedings of the 18th Annual International Conference of the IEEE

Conference_Location

Amsterdam

Print_ISBN

0-7803-3811-1

Type

conf

DOI

10.1109/IEMBS.1996.656989

Filename

656989