Toxicity of direct nonthermal plasma treatment of living tissue

Non-thermal dielectric barrier discharge plasma applied directly on living tissues has various applications in skin sterilization, wound treatment, and treatment of malignant tissues. Non-thermal plasma has been shown to sterilize intact tissue without visible or microscopic damage, and our goal was to identify the boundaries of intact and wounded skin toxicity after DBD plasma treatment. Safe doses of plasma treatment of intact and wounded pig skin were determined. The earliest signs of intact skin damage occur at 0.50 W/cm². DBD plasma treatment is now being evaluated as a safe method for tissue sterilization of living tissue.