Title :
Design of creatinine-imprinted polymers
Author :
Chen, Wei-Chih ; Lin, Hung-Yin ; Chou, Tse-Chuan
Author_Institution :
Dept. of Chem. Eng., Nat. Cheng Kung Univ., Tainan, Taiwan
Abstract :
Creatinine level in blood or urine is associated with human renal function. A high-affinity functional monomer with creatinine in preparing creatinine-imprinted polymer could be used to increase binding capacity and improve sensing with creatinine. The most absorptive functional monomer was methacrylic acid (MAA) and the functional monomer sequence was MAA>2-hydroxyethylmethacrylate (HEMA)>N-vinyl pyrrolidone (NVP)≫4-vinyl pyridine (4VP). The selectivity of creatinine-imprinted polymer to creatine and uric acid, when MAA was used as the functional monomer, exceeded that obtained using HEMA as the functional monomer.
Keywords :
biochemistry; blood; chemical analysis; kidney; molecular biophysics; polymers; 2-hydroxyethylmethacrylate; 4-vinyl pyridine; N-vinyl pyrrolidone; binding capacity; blood; creatinine-imprinted polymers; functional monomer sequence; human renal function; methacrylic acid; uric acid; urine; Biochemistry; Blood; Chemical engineering; Diseases; Ethanol; Humans; Inductors; Kinetic theory; Methanol; Polymers;
Conference_Titel :
Bioengineering Conference, 2005. Proceedings of the IEEE 31st Annual Northeast
Print_ISBN :
0-7803-9105-5
Electronic_ISBN :
0-7803-9106-3
DOI :
10.1109/NEBC.2005.1431915
