Pharmaco-informatics: Predicting an ayurvedic treatment for Hirschsprung´s disease

Author

Somashekhar, R. ; Mahesh, M. ; Bagchi, Preenon ; Rajesh, T.S.

Author_Institution

Azyme Biosci., Bangalore, India

fYear

2009

fDate

9-11 Dec. 2009

Firstpage

245

Lastpage

250

Abstract

Hirschsprung´s disease, or HD, is a disease of the large intestine. Mutations in the RET gene is one of the cause of Hirschsprung´s disease, HD. Homo sapiens ret proto-oncogene AAH04257 from NCBI database was taken for this work. Homology modeling studies was done and 3D structure of RET protein was modeled. Tinospora is an Ayurvedic Herb. The structure of Tinospora was made and converted to Tinospora.pdb. The receptor RET protein and the ligand Tinospora.pdb (proposed treatment) were docked.

Keywords

CAD; bioinformatics; medical computing; patient treatment; solid modelling; 3D RET protein structure; AAH04257 proto-oncogene; Hirschsprung disease; ayurvedic treatment; homology modeling; pharmaco-informatics; Amino acids; Databases; Diseases; Endocrine system; Genetic mutations; High definition video; Intestines; Muscles; Neoplasms; Proteins; Ayurveda; Bioinformatics; CADD; Constipation; Dock; Energy Minimization; Homology modeling; Large intestine; Multiple endocrine neoplasia; Mutation; Proto-oncogene; Template; Tinospora; database;

fLanguage

English

Publisher

ieee

Conference_Titel

Nature & Biologically Inspired Computing, 2009. NaBIC 2009. World Congress on

Conference_Location

Coimbatore

Print_ISBN

978-1-4244-5053-4

Type

conf

DOI

10.1109/NABIC.2009.5393705

Filename

5393705