Title :
An In-silico approach towards remediation of Schizophrenia
Author :
Bagchi, Preenon ; Somashekhar, R. ; Kalidass, S.
Author_Institution :
Punjab Tech. Univ., Jalandhar, India
Abstract :
Mutant protein hSKCa3 responsible for Schizophrenia is taken from NCBI´s Entrez database; its 3D structure is determined by homology modelling. The conotoxin protein is taken from NCBI´s Entrez database & its 3D structure is established. The structure of Withanolide is determined and docked with conotoxin protein; this combination is docked with hSKCa3 protein, hence establishing a remedy.
Keywords :
CAD; bioinformatics; database management systems; drugs; medical computing; neurophysiology; proteins; solid modelling; 3D structure; NCBI Entrez database; Schizophrenia remediation; Withanolide structure; computer aided drug designing; conotoxin protein; hSKCa3 protein; homology modelling; in-silico approach; mutant protein hSKCa3; neurological disorder; Amino acids; Biotechnology; Databases; Drugs; Medical diagnostic imaging; Medical treatment; Neuroscience; Peptides; Proteins; Switches; Ayurveda; Computer Aided Drug Designing; Neuroscience; docking; homology modelling; neurotoxin;
Conference_Titel :
Nature & Biologically Inspired Computing, 2009. NaBIC 2009. World Congress on
Conference_Location :
Coimbatore
Print_ISBN :
978-1-4244-5053-4
DOI :
10.1109/NABIC.2009.5393709
