Tissue ablation using multi-frequency focused ultrasound

In this study, experiments and simulations on tissue ablation were performed to investigate the effectiveness of multi-frequency focused ultrasound (FUS) with frequency differences more than 500 kHz (950 kHz, 1.5 MHz and 3.3 MHz FUS). In tissue ablation tests, temperature rise was recorded when chicken breast tissue was ablated by FUS with single-frequency and multi-frequency ultrasound, respectively, at controlled acoustic power and exposure time. Simulations have been performed to verify the temperature change and distribution in these tests. Distinct temperature rise differences were observed between single-frequency modes and dual-frequency modes, indicating that dual-frequency FUS is more effective on the rate of temperature rise. This finding is promising for ultrasound surgery.