Title :
Three-dimensional quantitative high-frequency characterization of freshly-excised human lymph nodes
Author :
Mamou, Jonathan ; Saegusa-Beecroft, Emi ; Coron, Alain ; Oelze, Michael L. ; Yamaguchi, Tadashi ; Machi, Junji ; Hata, Masaki ; Yanagihara, Eugene ; Laugier, Pascal ; Feleppa, Ernest J.
Author_Institution :
Riverside Res., Frederic L. Lizzi Center for Biomed. Eng., New York, NY, USA
Abstract :
High-frequency quantitative ultrasound (QUS) permits characterization of tissue microstructure using system-independent estimates. In this study, freshly-excised lymph nodes from cancer patients were evaluated using specifically designed three-dimensional (3D) QUS methods. The long-term objective was to develop 3D QUS methods for detecting metastases. Detection of metastases is critically important for cancer staging and treatment planning. A custom laboratory scanning system was used to acquire radio-frequency (RF) data in 3D from excised lymph nodes using a 26-MHz center-frequency transducer. Overlapping 1-mm cylindrical regions-of-interest (ROIs) of the RF data were processed to yield 13 QUS estimates associated with tissue microstructure. QUS estimates were obtained from more than 250 nodes from more than 150 colorectal-, gastric-, and breast-cancer patients. Cancer-detection performance was assessed for individual estimates and linear combinations of estimates. ROC results demonstrated excellent classification. For colorectal- and gastric-cancer nodes, the areas under the ROC curves (AUCs) were above 0.94. Slightly poorer results (AUC 0.87) were obtained for breast nodes. Images based on QUS parameters also permitted localization of cancer foci in some micrometastatic cases. Therefore, these advanced 3D QUS methods potentially can be valuable for detecting small metastatic foci in dissected lymph nodes.
Keywords :
biological tissues; biomedical transducers; biomedical ultrasonics; cancer; cellular biophysics; image classification; medical image processing; patient treatment; sensitivity analysis; ultrasonic transducers; 3D QUS methods; 3D quantitative high-frequency characterization; QUS parameters; RF data; ROC curves; breast nodes; breast-cancer patient; cancer foci; cancer staging; cancer treatment planning; cancer-detection performance; center-frequency transducer; colorectal-cancer nodes; colorectal-cancer patient; custom laboratory scanning system; dissected lymph nodes; frequency 26 MHz; freshly-excised human lymph nodes; gastric-cancer nodes; gastric-cancer patient; high-frequency quantitative ultrasound; metastase detection; micrometastatic cases; radiofrequency data; tissue microstructure; Acoustics; Breast cancer; Lymph nodes; Radio frequency; Transducers; Ultrasonic imaging; high-frequency ultrasound; lymph node; metastasis; quantitative ultrasound;
Conference_Titel :
Ultrasonics Symposium (IUS), 2011 IEEE International
Conference_Location :
Orlando, FL
Print_ISBN :
978-1-4577-1253-1
DOI :
10.1109/ULTSYM.2011.0010