Genome-wide alternative splicing events detection through analysis of large scale ESTs

Author

Hsu, F.R. ; Chang, Hwan-You ; Lin, Yaw-Lin ; Tsai, Yin-Te ; Peng, Hui-Ling ; Chen, Ying Tsong ; Chen, Che Feng ; Cheng, Chia Yang ; Liu, Chia-Hung ; Shih, Min Yao

Author_Institution

Dept. of Inf. Technol., Taichung Healthcare & Manage. Univ., Taiwan

fYear

2004

fDate

19-21 May 2004

Firstpage

310

Lastpage

316

Abstract

In the past several years, the analysis of alternative splicing and its application to identify the origins of disease has been gaining momentum. Therefore, we developed a value added transcriptome database (Avatar). We mapped EST (expressed sequence tag) and mRNA sequences onto whole human genomic sequence. We identified 9,937 alternative splicing relationships genes through an analysis of large-scale ESTs. Besides, we provided alternative splicing information for six organisms: Homo sapiens, Mus musculus, Rattus norvegiens, Caenorhabditis elegans, Drosophila melanogaster and Arabidopsis thaliana.

Keywords

biology computing; genetics; medical computing; sequences; Arabidopsis thaliana; Avatar; Caenorhabditis elegans; Drosophila melanogaster; EST; Homo sapiens; Mus musculus; Rattus norvegiens; alternative splicing events detection; expressed sequence tag; genome; mRNA sequences; transcriptome database; Avatars; Bioinformatics; Databases; Diseases; Event detection; Genomics; Humans; Large-scale systems; Organisms; Splicing;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Bioengineering, 2004. BIBE 2004. Proceedings. Fourth IEEE Symposium on

Print_ISBN

0-7695-2173-8

Type

conf

DOI

10.1109/BIBE.2004.1317358

Filename

1317358