DocumentCode
323230
Title
Dynamic analysis of the interaction of radiation with tissue
Author
Bernard, John A. ; Hu, Lin Wen
Author_Institution
MIT, Cambridge, MA, USA
fYear
1997
fDate
9-15 Nov 1997
Firstpage
487
Abstract
A macroscopic model of the effects of radiation on tissue is developed from a description in space, time, and energy of the chemical reactions that constitute direct and indirect attack as well as repair. The model assumes first-order kinetics. The resulting equations are combined through a process of differentiation and substitution to obtain a single analytic expression, the dynamic response equation. Solution of this equation allows calculation of the parameter plotted in dose response studies and is used here to show that the surviving fraction depends on both dose and dose rate
Keywords
DNA; cellular effects of radiation; dosimetry; DNA; chemical reactions; dose rate; dose response; dynamic response equation; first-order kinetics; macroscopic model; radiation; repair; tissue; Atomic measurements; Chemical analysis; Chemical technology; DNA; Differential equations; Ionization; Ionizing radiation; Predictive models; Space technology; Writing;
fLanguage
English
Publisher
ieee
Conference_Titel
Nuclear Science Symposium, 1997. IEEE
Conference_Location
Albuquerque, NM
ISSN
1082-3654
Print_ISBN
0-7803-4258-5
Type
conf
DOI
10.1109/NSSMIC.1997.672630
Filename
672630
Link To Document