DocumentCode :
3233627
Title :
Comparison between Acoustic Radiation Force Impulse (ARFI)-based hepatic stiffness quantification in deformed and undeformed pressurized canine livers
Author :
Rotemberg, Veronica ; Palmeri, Mark L. ; Rouze, Ned C. ; Nightingale, Roger ; Nightingale, Kathryn R.
Author_Institution :
Dept. of Biomed. Eng., Duke Univ., Durham, NC, USA
fYear :
2011
fDate :
18-21 Oct. 2011
Firstpage :
2090
Lastpage :
2093
Abstract :
Increased hepatic interstitial pressure can be observed in patients with advanced liver disease and is associated with worsened clinical outcomes. Elevated hepatic stiffness has been reported clinically with increases in hepatic venous pressure gradient (HVPG). An experiment was designed to determine whether stiffness increase exhibited with hepatic pressurization results from a strain-dependent hyperelastic behavior. Six excised canine livers were subjected to variations in interstitial pressure through cannulation of the portal vein and closure of the hepatic artery and hepatic vein under constrained conditions (in which the liver was not free to expand) and unconstrained conditions. Radiation force derived shear wave speed estimates were obtained and correlated with pressure. Estimates of hepatic shear stiffness increased with changes in interstitial pressure over a physiologically relevant range of pressures (0-35mmHg) from 1.5 to 3.5 m/s. These increases were observed only under conditions in which the liver was free to expand while pressurized.
Keywords :
biomechanics; biomedical measurement; biomedical ultrasonics; blood vessels; diseases; elastic deformation; elastic waves; elasticity; liver; shear deformation; acoustic radiation force impulse; advanced liver disease; elevated hepatic stiffness; hepatic artery; hepatic interstitial pressure; hepatic shear stiffness; hepatic stiffness quantification; hepatic vein; hepatic venous pressure gradient; liver; portal vein; pressurized canine livers; radiation force; shear wave speed estimation; strain-dependent hyperelastic behavior; Acoustics; Force; Liver diseases; Portals; Ultrasonic imaging; Veins;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Ultrasonics Symposium (IUS), 2011 IEEE International
Conference_Location :
Orlando, FL
ISSN :
1948-5719
Print_ISBN :
978-1-4577-1253-1
Type :
conf
DOI :
10.1109/ULTSYM.2011.0518
Filename :
6293600
Link To Document :
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