Development of transdermal delivery chip system: Deliver gold nanoparticles into human stratum corneume

This paper reports a transdermal delivery chip system for delivering gold nanoparticles (AuNPs) into human stratum corneum (HSC). The proposed transdermal delivery chip system could provide electrostatic force to drive AuNPs which were then delivered into HSC via intercellular route. Various DC voltages (3, 6, and 9 V) were employed to generate electric field of different intensities (3.2~9.8 V/cm) as a role to drive AuNPs into HSC. Results show permeability of the skin increases with the electric field intensities. We use MEMS technology to design and fabricate the proposed chip system. The proposed transdermal delivery chip system will provide many potential usages for biomedical applications.