Interactive 3D visualization of actual anatomy and simulated chemical time-course data for fish

Outputs from a physiologically based toxicokinetic (PB-TK) model for fish were visualized by mapping time series data for specific tissues onto a three dimensional representation of a rainbow trout. The trout representation was generated in stepwise fashion: cross sectional images were obtained from an anesthetized fish using a magnetic resonance imaging (MRI) system; images were processed to classify tissue types; images were stacked and processed to create a three dimensional representation of the fish, encapsulating five volumes corresponding to the liver, kidney, muscle, gastrointestinal tract, and fat. Kinetic data for the disposition of pentachloroethane in trout were generated using a PB-TK model. Model outputs were mapped onto corresponding tissue volumes, representing chemical concentration as color intensity. The visualization was then animated, to show the accumulation of pentachloroethane in each tissue during a continuous branchial (gill) exposure