Release of product inhibition in fermentation process

Product feedback inhibitions exist in the industrial fermentation process, and limit the production performance of fermentation. Integration of fermentation and separation of fermentative products is the major way to release product inhibition. In-situ separations remove products from the culture media in a timely manner in the fermentation process. It could reduce product inhibition, control pH, and improve the utilization of raw materials and product yield. This paper describes several commonly used product separation methods, with emphasis on applications and advantages of bipolar membrane electrodialysis in fermentative products separation.