Full custom design of the interface for an in vitro neural biosensor

This paper describes the interface design for an in vitro neural biosensor which tends to combine biological neural network and integrated circuits together in a micro-system for intelligent bio-computation. As a simple case, design and fabrication process for the 4×4 microelectrode-array (MEA) that interfaces neural tissue with circuits is presented in detail. The experimental results have primarily demonstrated good performance of the MEA that was fabricated in IC Manufacture Center for IME of Tsinghua University. A tentative 256 × 256 MEA containing two 128 × 128 MEAs (one for stimulation while the other for recording) for the final biosensor can hopefully arise from it by the same token. Additionally, we also briefly present the front-end design for the neural recording in this paper.