CMOS heater array for incubation environment cellular study

Author

Blain Christen, Jennifer M. ; Andreou, Andreas G.

Author_Institution

Dept. of Electr. & Comput. Eng., Johns Hopkins Univ., Baltimore, MD

fYear

2005

fDate

7-10 Aug. 2005

Firstpage

1786

Abstract

We have designed a serial interface heater array with biocompatible packaging. Several different adhesion factors were tested for each of the materials used in the packaging to determine the best overall surface preparation for cell culture on a commercially fabricated CMOS die with PDMS packaging. The heaters were individually tested to determine the variations over the array. The heater array was calibrated to determine resistance values for each element of the array. Once calibrated the heater array can be used to control the temperature of an arbitrary set of locations to any temperature up to 85degC. The array can also be used in incubation mode for either incubation or to maintain the cells during testing

Keywords

CMOS integrated circuits; cellular biophysics; heating; integrated circuit packaging; polymers; 85 C; CMOS heater array; PDMS packaging; biocompatible packaging; cell culture; incubation environment cellular study; Biological materials; Cleaning; Ethanol; Optical buffering; Packaging; Plasma temperature; Resistance heating; Surface contamination; Testing; Wire;

fLanguage

English

Publisher

ieee

Conference_Titel

Circuits and Systems, 2005. 48th Midwest Symposium on

Conference_Location

Covington, KY

Print_ISBN

0-7803-9197-7

Type

conf

DOI

10.1109/MWSCAS.2005.1594468

Filename

1594468