Decoupled adaptive control of glucose and dissolved oxygen for fed-batch methionine production using linear reference model

In this paper, the design of a decoupled adaptive controller for controlling the dissolved oxygen and glucose feeding simultaneously in fed-batch fermentation of methionine production is proposed. The synthesis of methionine at the cellular level is strictly regulated and its process dynamics shows a nonlinear interaction between dissolved oxygen and glucose concentration. The adaptive controller developed using a linear reference model for controlling these two variables, is designed in such a way that the system is decoupled. The performance of adaptive controller is evaluated in terms of simultaneous set point and trajectory tracking of dissolved oxygen (c_L) and glucose (s) concentration Convergence of parameters is guaranteed by the Kalman-Meyer-Yakubovich criteria.