The effects of formalin fixing on terahertz properties of biological samples

Author

Sun, Yiwen ; Pickwell-MacPherson, Emma

Author_Institution

Dept. of Electron. Eng., Chinese Univ. of Hong Kong, Hong Kong

fYear

2008

fDate

15-19 Sept. 2008

Firstpage

1

Lastpage

2

Abstract

Terahertz radiation is sensitive to covalently cross-linked proteins and can be used to probe unique spectroscopic signatures. In this paper we demonstrate how the terahertz properties of tissue are affected by formalin fixing. We study the detailed changes arising from different fixation times and see that formalin fixing reduces the refractive index and the absorption coefficient of our samples in the terahertz regime.

Keywords

absorption coefficients; biological effects of microwaves; biological tissues; molecular biophysics; molecular configurations; proteins; refractive index; terahertz wave spectra; absorption coefficient; biological samples; covalently cross-linked proteins; formalin fixing; refractive index; terahertz radiation; tissue; Biomedical optical imaging; Frequency; Optical pulses; Optical refraction; Optical sensors; Optical variables control; Proteins; Refractive index; Spectroscopy; Ultrafast optics;

fLanguage

English

Publisher

ieee

Conference_Titel

Infrared, Millimeter and Terahertz Waves, 2008. IRMMW-THz 2008. 33rd International Conference on

Conference_Location

Pasadena, CA

Print_ISBN

978-1-4244-2119-0

Electronic_ISBN

978-1-4244-2120-6

Type

conf

DOI

10.1109/ICIMW.2008.4665719

Filename

4665719